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Acod1/itaconate activates Nrf2 in pulmonary microvascular endothelial cells to safeguard against the obesity-induced pulmonary microvascular endotheliopathy Li ZhuPlasma and brains have been collected at the end of the study. Baseline groups of naïve (untreated) rTg4510 mice had been also sacrificed at 8 or twelve weeks of age (n = 10 per age g